The Philadelphia Eagles have struggled in the red zone over the course of their two-game losing streak. Things won't get any easier this week, as the club will be without running back Brian Westbrook when it takes on the San Francisco 49ers Sunday at Candlestick Park.

Randy Moss caught five passes for 111 yards and scored one touchdown to lead the New England Patriots to a 30-21 victory over the San Francisco 49ers in Week 5 action.

Hopefully for the sake of the San Francisco 49ers, J.T. O'Sullivan learned something in the month he was employed by the New England Patriots.

Drew Brees completed 23-of-35 passes for 363 yards and three touchdowns, and the New Orleans Saints routed the San Francisco 49ers, 31-17.

The NFL's top passing offense collides with one of the best passing defenses in the league so far this year on Sunday, when Drew Brees and the high-flying New Orleans Saints battle Justin Smith and the San Francisco 49ers at the Superdome.

The San Francisco 49ers announced Thursday they will retire the jersey No. 8 of former quarterback Steve Young, the 11th player to be so honored in team history.

San Francisco 49ers cornerback Shawntae Spencer will undergo surgery on Wednesday to repair a torn ACL in his left knee.

J.T. O'Sullivan threw for 189 yards and two touchdowns on 16-of-23 passing, while Frank Gore tallied 130 yards on 27 attempts with a score and added four grabs for 32 yards to lead the San Francisco 49ers past the Detroit Lions, 31-13, in Week 3 action.

Given a rare chance to start, J.T. O'Sullivan nearly doubled his career passing yardage total in one game last week. The journeyman quarterback will now try to haunt his former team this Sunday, when his San Francisco 49ers play host to the Detroit Lions at Candlestick Park.

Dominant play against fellow NFC West residents has helped the Seattle Seahawks capture four straight division titles. Seattle will open up 2008 divisional play this Sunday with a home test against the San Francisco 49ers at Qwest Field.

The San Francisco 49ers placed quarterback Alex Smith on injured reserve Wednesday because of a shoulder injury and signed quarterback Jamie Martin to take Smith's spot on the 53-man roster.

Kurt Warner was an efficient 19-of-30 for 197 yards and a touchdown as the Arizona Cardinals edged the San Francisco 49ers, 23-13 in the season opener for both NFC West squads.

When the San Francisco 49ers and Arizona Cardinals opened the 2007 season against each other by the bay, both teams had their respective quarterbacks of the future under center. Yet, those two former first-round picks will both be on the bench this weekend when the two clubs again open their season against one another at Candlestick Park.

Wide receiver Ashley Lelie, fullback Moran Norris, and defensive tackle LaJuan Ramsey were among the notables released by the San Francisco 49ers on Saturday, as Mike Nolan's club reduced its roster to the 53-player maximum.

Eldra Buckley's touchdown catch with 29 seconds to play lifted the San Diego Chargers to a 20-17 win over the San Francisco 49ers in the preseason finale for both squads.

That last thing that the San Francisco 49ers expected to have three years after taking Alex Smith first overall in the 2005 draft was uncertainty at the quarterback position.

The San Francisco 49ers named J.T. O'Sullivan their starting quarterback Friday.

J.T. O'Sullivan completed 7-of-8 passes for 126 yards and a touchdown as San Francisco outgunned Chicago, 37-30, in preseason action from Soldier Field.

J.T. O'Sullivan threw for 154 yards and one score on 8-of-17 passing to lead the San Francisco 49ers to a 34-6 romp over the Green Bay Packers in preseason play.